⚠ Research Use Only: All content is for qualified researchers conducting in-vitro laboratory studies. Not for human consumption or veterinary use.
What is MT2 (Melanotan 2)?
MT2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). Unlike its predecessor Melanotan 1, MT2 is cyclic with enhanced receptor binding affinity and broader melanocortin receptor activity. Key properties:
- Molecular formula: C50H69N15O9 · MW: 1024.18 g/mol
- Structure: Cyclic heptapeptide lactam analog of α-MSH
- Half-life: ~33 hours (vs minutes for natural α-MSH)
- Highly photosensitive — must be protected from light at all times
Melanocortin Receptor Activity
| Receptor | MT2 Affinity (IC50) | Primary Function |
|---|---|---|
| MC1R | ~1–3 nM | Melanogenesis, pigmentation |
| MC3R | ~1–5 nM | Energy homeostasis |
| MC4R | ~1–5 nM | Appetite, sexual function |
| MC5R | ~5–10 nM | Exocrine gland function |
MT2 Reconstitution Protocol
- Calculate concentration: For a 10mg vial, add 2mL BAC water → 5mg/mL (5000mcg/mL).
- Prepare workspace: Sterile surface, gloves, allow refrigerated vials to reach room temperature.
- Clean rubber stopper: Wipe with alcohol swab, let dry 30 seconds.
- Draw BAC water: Use 18–22 gauge needle, switch to 27–30 gauge for vial injection.
- Add diluent slowly: Inject down the vial wall at 45°. Never onto powder.
- Dissolve: Swirl gently 2–3 minutes until clear. Never shake.
- Light protection — critical: Immediately wrap in aluminum foil. MT2 degrades rapidly on light exposure.
- Label and refrigerate: Concentration, date, expiry. Store at 2–8°C.
⚠ Light Protection is Essential: MT2 contains tryptophan residues that are highly susceptible to photo-oxidation. Even brief light exposure reduces potency by 10–20%. Always work quickly and wrap vials immediately.
Research Dosing Protocols
| Phase | Dosage Range | Frequency |
|---|---|---|
| Loading Phase | 0.5–1.0 mg | Daily, 5–10 days |
| Maintenance Phase | 0.25–0.5 mg | 2–3× per week |
| Low-dose Research | 0.25–0.5 mg | 2–3× per week |
Dosing Calculations (at 5mg/mL concentration)
- 0.25mg dose → 0.05mL (5 units on insulin syringe)
- 0.5mg dose → 0.10mL (10 units)
- 0.75mg dose → 0.15mL (15 units)
- 1.0mg dose → 0.20mL (20 units)
Common Research Observations
- Melanogenesis: Increased pigmentation via MC1R in appropriate models
- Appetite suppression: MC4R-mediated reduction in food intake
- Nausea (20–40%): Transient, typically resolves within 60 minutes. Starting with lower doses reduces incidence.
- Facial flushing (10–20%): Temporary vasodilation, resolves in 1–2 hours
Storage Guidelines
- Lyophilized: −20°C, up to 24 months. Keep in original sealed packaging.
- Reconstituted: 2–8°C refrigerator, up to 28 days with BAC water.
- Always wrapped in foil — protect from all light sources at all times.
- Never freeze reconstituted solution — ice crystals degrade the peptide.
Buy Research-Grade Melanotan 2 (MT2) in Europe
10mg · ≥98% purity · HPLC tested · COA included · Discreet shipping across Europe
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